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Publication – Evaluation of the External RNA Controls Consortium (ERCC) reference material using a modified Latin square design

The External RNA Controls Consortium and collaborators have published a paper evaluating reference materials which were used to develop the NIST Standard Reference Material (SRM) 2374. The paper is publicly available at the links below. Evaluation of the External RNA Controls Consortium (ERCC) reference material using a modified Latin square design. P Scott Pine, Sarah Mu...

External RNA Controls Consortium – Call for Participation and Contributions to a Sequence Library

ERCC 2.0 Call for Participation and Collection of New ERCC Sequences Published in Federal Register: NIST is reconvening the External RNA Controls Consortium (ERCC), a public, private, and academic research collaboration to develop external RNA controls for gene expression assays. ERCC products are being extended to accommodate recently emerged applications. This is a call...

SRM 2374 – DNA Sequence Library for External RNA Controls

When ERCC members developed the RNA spike-in controls, they contributed RNA sequences designed to mimic, but not interfere with, mammalian RNA. The result of this collaborative effort was SRM 2374, a set of 96 DNA templates used to make ERCC RNA control molecules. The 96 plasmid set, SRM 2374, is available for purchase directly through NIST. By adding mixtures of ERCC contro...